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HomeFusion Plasma Encyclopedia
Scientific Knowledge Base

Fusion PlasmaEncyclopedia

Deep-dive scientific content for clinical professionals. From the physics of plasma to treatment protocols — the complete knowledge base behind Fusion Plasma technology.

Chapter 08
7 min read
Real Footage

Applications

Discover the Potential of Cold Plasma Uses

Properties, Research and Clinical Practice

Select Chapter
01What is Plasma?02How Cold Plasma Works03Warm Plasma Technology04ROS & RNS in Aesthetics05Clinical Protocols06Safety & Contraindications07What Is a Cold Plasma Device and How Does It Work?08Discover the Potential of Cold Plasma Uses09What Is Fusion Plasma?10How to Choose a Plasma Device for Your Clinic11How Does Fusion Plasma Work?
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Select Chapter
01What is Plasma?02How Cold Plasma Works03Warm Plasma Technology04ROS & RNS in Aesthetics05Clinical Protocols06Safety & Contraindications07What Is a Cold Plasma Device and How Does It Work?08Discover the Potential of Cold Plasma Uses09What Is Fusion Plasma?10How to Choose a Plasma Device for Your Clinic11How Does Fusion Plasma Work?

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08

Chapter Overview

Discover the Potential of Cold Plasma Uses

Cold plasma technology has become one of the most interesting innovations in professional care. Its properties and versatile applications have drawn attention in aesthetics and in scientific research alike. This article gives an overview of how cold plasma works, where it is used and what to consider when introducing it in a clinic.

01 of 07

Understanding cold plasma

Cold plasma, also called non-thermal plasma, is a partially ionized gas containing ions, electrons and neutral particles at near-room temperature. Unlike plasmas that require extremely high temperatures, cold plasma is gentle enough for direct contact with the skin.

02 of 07

Key properties of cold plasma

  • Reactive species: Cold plasma produces reactive oxygen and nitrogen species that interact with cells and microorganisms.
  • Non-thermal operation: It can be applied to delicate skin without burns.
  • Antimicrobial effect: Studies show that cold plasma reduces bacteria, viruses and fungi on surfaces and on the skin.
  • Support for renewal: Research describes stimulation of cellular renewal and collagen.
03 of 07

Cold plasma in aesthetics

Skin rejuvenation

Cold plasma supports the skin's own renewal and collagen production, which can improve elasticity, the appearance of fine lines and wrinkles, and skin texture. Treatments are minimally invasive with little or no downtime.

Skin care and hygiene

Its antimicrobial properties make cold plasma useful for acne-prone skin and for hygiene in professional settings.

04 of 07

Cold plasma in scientific research

Universities and hospitals around the world study cold plasma in many fields, including wound care, dentistry, oncology and the disinfection of instruments. These are research areas of plasma medicine, carried out with specialized medical equipment. Fusion Plasma is a cosmetic device and is not intended to diagnose or treat disease. A selection of published studies is listed in our encyclopedia.

05 of 07

Innovations behind modern cold plasma devices

  • User-friendly devices: Modern devices are compact and easy to operate in clinics and aesthetic practices.
  • Precise delivery: Controlled plasma generation and interchangeable tips allow precise, repeatable applications. Fusion Plasma's technology is protected by Turkish patent TR 2023 008123 B.
  • Combination with other methods: Cold plasma is increasingly combined with other aesthetic methods to broaden the range of applications.
  • Research and development: Ongoing work focuses on plasma parameters, biological interactions and new application protocols.
06 of 07

Practical recommendations for clinics

Training and certification

Proper training is essential to understand the device, safety rules and techniques. Fusion Plasma devices come with training and certification.

Client assessment

Assess each client individually. Skin type, health history and goals should guide the choice of settings and the number of sessions. See safety and contraindications.

Maintenance

Regular maintenance and following the manufacturer's instructions keep performance and safety consistent.

Network and support

Working with a network of professionals and authorised distributors gives access to experience and the latest developments. Become a distributor or contact us.

Documentation

Recording settings and results for every session supports continuous improvement.

07 of 07

The future of cold plasma

  • New applications as research continues
  • More personalized treatments through finer control of plasma settings
  • Wider access through distributor networks
  • An energy-efficient, chemical-free technology

Fusion Plasma — headquarters and production in Türkiye, R&D in several countries and a training and management arm in the United States — is the original cold and warm plasma platform for professional aesthetics. Cold plasma technology offers professionals powerful tools to raise the quality of their services, today and in the future.

Chapter Summary

What cold plasma is, the properties that make it useful, where researchers and professionals are applying it, and practical advice for clinics that want to start.

Visual Documentation

Real Atmospheric Plasma Generated by Fusion Plasma

Unlike conventional illustrations, these images show actual atmospheric plasma generated by the Fusion Plasma system using controlled ionization of argon gas under atmospheric pressure.

Hyper Plasma Tip — Live Discharge
Original Product Photo

Hyper Plasma Tip — Live Discharge

Cold plasma from the Hyper tip on skin during a session

Cold Plasma Filaments
Original Product Photo

Cold Plasma Filaments

Argon plasma filaments at the Hyper tip

Derma Plasma Tip
Original Product Photo

Derma Plasma Tip

Cold plasma pins of the Derma tip

Clinical Application
Original Product Photo

Clinical Application

Hyper tip in use on a client

Hyper Plasma Tip
Original Product Photo

Hyper Plasma Tip

Argon plasma glowing inside the Hyper tip

Scientific Research

Published research on cold plasma

Cold atmospheric plasma is a broad field of scientific research carried out at universities and hospitals around the world. Below is a selection of peer-reviewed reviews and clinical studies.

These publications concern cold plasma technology in general; they were not conducted with Fusion Plasma devices. Fusion Plasma is a CE-certified cosmetic device and is not intended to diagnose or treat disease.

Reviews

  1. Cold atmospheric plasma (CAP): a revolutionary approach in dermatology and skincare

    Khalaf AT, Abdalla AN, Ren K, Liu X · European Journal of Medical Research 29:487 · 2024

    Recent review of cold plasma in dermatology, skin health and skincare.

  2. Plasma Dermatology: Skin Therapy Using Cold Atmospheric Plasma

    Tan F, Wang Y, Zhang S, Shui R, Chen J · Frontiers in Oncology 12:918484 · 2022

    Review of the effects of cold plasma on skin lipids, cells, histology and blood circulation, and its study in wound healing, inflammatory and infectious skin conditions and alopecia.

  3. Cold atmospheric plasma applications in dermatology: A systematic review

    Gan L, et al. · Journal of Biophotonics 14(3):e202000415 · 2021

    Systematic review of 166 studies on cold atmospheric plasma in dermatology, searched in PubMed, Embase and Web of Science.

  4. Plasma Medicine: A Field of Applied Redox Biology

    von Woedtke T, Schmidt A, Bekeschus S, Wende K, Weltmann KD · In Vivo 33(4):1011–1026 · 2019

    Explains that biological plasma effects are mainly mediated by reactive oxygen and nitrogen species, and describes the dose-dependent effects of cold plasma.

  5. Plasma Medicine: Applications of Cold Atmospheric Pressure Plasma in Dermatology

    Bernhardt T, et al. · Oxidative Medicine and Cellular Longevity 2019:3873928 · 2019

    Review of cold atmospheric plasma in dermatology: antimicrobial, anti-inflammatory and tissue-stimulating effects, and the plasma sources in use.

  6. Plasma medicine: possible applications in dermatology

    Heinlin J, et al. · JDDG – Journal der Deutschen Dermatologischen Gesellschaft 8(12):968–976 · 2010

    Overview of possible dermatological uses of plasma, including tissue regeneration and skin infections.

  7. Plasma medicine: an introductory review

    Kong MG, Kroesen G, Morfill G, et al. · New Journal of Physics 11:115012 · 2009

    Introductory review of the field: how room-temperature, atmospheric-pressure plasmas work and where they can be used in health care and hygiene.

Clinical studies

  1. A Prospective, Randomised, Controlled, Split-Face Clinical Trial to Assess the Safety and the Efficacy of Cold Atmospheric Plasma in the Treatment of Acne Vulgaris

    Karrer S, et al. · Applied Sciences 11(23):11181 · 2021

    Split-face trial (34 patients): cold helium plasma was safe and well tolerated, with a moderate reduction in acne lesions and better patient ratings of appearance on the treated side.

  2. Successful and safe use of 2 min cold atmospheric argon plasma in chronic wounds: results of a randomized controlled trial

    Isbary G, et al. · British Journal of Dermatology 167(2):404–410 · 2012

    Randomized controlled study (24 patients): 2-minute cold argon plasma treatments reduced bacterial load without side effects.

  3. A first prospective randomized controlled trial to decrease bacterial load using cold atmospheric argon plasma on chronic wounds in patients

    Isbary G, et al. · British Journal of Dermatology 163(1):78–82 · 2010

    Randomized controlled phase II study (38 wounds, 36 patients): daily cold argon plasma reduced bacterial load in treated wounds by 34% and was well tolerated.

  4. Evaluation of plasma skin regeneration technology in low-energy full-facial rejuvenation

    Bogle MA, Arndt KA, Dover JS · Archives of Dermatology 143(2):168–174 · 2007

    Small study (8 volunteers) of thermal nitrogen-plasma skin regeneration: three low-energy full-face treatments improved facial wrinkles and appearance with short recovery.

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