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HomeFusion Plasma Encyclopedia
Scientific Knowledge Base

Fusion PlasmaEncyclopedia

Deep-dive scientific content for clinical professionals. From the physics of plasma to treatment protocols — the complete knowledge base behind Fusion Plasma technology.

Chapter 07
4 min read
Real Footage

Guide

What Is a Cold Plasma Device and How Does It Work?

Controlled Low-Temperature Energy in Aesthetics

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01What is Plasma?02How Cold Plasma Works03Warm Plasma Technology04ROS & RNS in Aesthetics05Clinical Protocols06Safety & Contraindications07What Is a Cold Plasma Device and How Does It Work?08Discover the Potential of Cold Plasma Uses09What Is Fusion Plasma?10How to Choose a Plasma Device for Your Clinic11How Does Fusion Plasma Work?
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Select Chapter
01What is Plasma?02How Cold Plasma Works03Warm Plasma Technology04ROS & RNS in Aesthetics05Clinical Protocols06Safety & Contraindications07What Is a Cold Plasma Device and How Does It Work?08Discover the Potential of Cold Plasma Uses09What Is Fusion Plasma?10How to Choose a Plasma Device for Your Clinic11How Does Fusion Plasma Work?

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07

Chapter Overview

What Is a Cold Plasma Device and How Does It Work?

Cold plasma is a controlled energy technology used in professional aesthetic procedures to support the skin's natural renewal processes. Unlike high-heat devices, cold plasma works at low temperatures, without thermal damage to the skin.

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What is a cold plasma device?

A cold plasma device is a professional aesthetic tool that turns a gas such as argon or helium into plasma — an ionized gas — and applies it to the skin surface. This interaction supports oxygenation and the skin's own renewal processes.

Fusion Plasma, invented by Emrah Seyfi Tatar, is designed to deliver stable and controlled plasma energy for consistent results across many applications.

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How does cold plasma work?

The device creates a controlled stream of ionized particles and reactive species that interact with the skin. Research on cold atmospheric plasma describes effects such as support for collagen and elastin, improved microcirculation and support for the skin's natural regeneration. You can read the details, with links to published studies, in our encyclopedia.

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Cold plasma compared with high-heat devices

High-heat devices work with strong thermal energy, which can mean more skin stress and longer recovery. Cold plasma works without excessive heat, so treatments are gentler, recovery is typically shorter and results are easier to control.

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What can cold plasma be used for?

In professional aesthetics, cold plasma is used for the appearance of fine lines and skin laxity, acne-prone skin and the appearance of scars, skin texture, scalp care and better absorption of care products.

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Is cold plasma safe?

When performed by trained professionals with the correct settings, yes. Fusion Plasma is a CE-certified cosmetic device made for professional use, and every device is delivered with training. See safety and contraindications.

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Who is cold plasma for?

Med spas, aesthetic practitioners and clinics looking for advanced, non-invasive technology.

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Why Fusion Plasma?

Stable energy, cold and warm plasma in one platform, interchangeable tips for many applications, and two models: the touchscreen Pro and the manual Cold&Warm.

Chapter Summary

Cold plasma technology offers gentle, controlled solutions for modern aesthetic procedures. Contact us to book a live demo and see Fusion Plasma in action.

Visual Documentation

Real Atmospheric Plasma Generated by Fusion Plasma

Unlike conventional illustrations, these images show actual atmospheric plasma generated by the Fusion Plasma system using controlled ionization of argon gas under atmospheric pressure.

Hyper Plasma Tip — Live Discharge
Original Product Photo

Hyper Plasma Tip — Live Discharge

Cold plasma from the Hyper tip on skin during a session

Cold Plasma Filaments
Original Product Photo

Cold Plasma Filaments

Argon plasma filaments at the Hyper tip

Derma Plasma Tip
Original Product Photo

Derma Plasma Tip

Cold plasma pins of the Derma tip

Clinical Application
Original Product Photo

Clinical Application

Hyper tip in use on a client

Hyper Plasma Tip
Original Product Photo

Hyper Plasma Tip

Argon plasma glowing inside the Hyper tip

Scientific Research

Published research on cold plasma

Cold atmospheric plasma is a broad field of scientific research carried out at universities and hospitals around the world. Below is a selection of peer-reviewed reviews and clinical studies.

These publications concern cold plasma technology in general; they were not conducted with Fusion Plasma devices. Fusion Plasma is a CE-certified cosmetic device and is not intended to diagnose or treat disease.

Reviews

  1. Cold atmospheric plasma (CAP): a revolutionary approach in dermatology and skincare

    Khalaf AT, Abdalla AN, Ren K, Liu X · European Journal of Medical Research 29:487 · 2024

    Recent review of cold plasma in dermatology, skin health and skincare.

  2. Plasma Dermatology: Skin Therapy Using Cold Atmospheric Plasma

    Tan F, Wang Y, Zhang S, Shui R, Chen J · Frontiers in Oncology 12:918484 · 2022

    Review of the effects of cold plasma on skin lipids, cells, histology and blood circulation, and its study in wound healing, inflammatory and infectious skin conditions and alopecia.

  3. Cold atmospheric plasma applications in dermatology: A systematic review

    Gan L, et al. · Journal of Biophotonics 14(3):e202000415 · 2021

    Systematic review of 166 studies on cold atmospheric plasma in dermatology, searched in PubMed, Embase and Web of Science.

  4. Plasma Medicine: A Field of Applied Redox Biology

    von Woedtke T, Schmidt A, Bekeschus S, Wende K, Weltmann KD · In Vivo 33(4):1011–1026 · 2019

    Explains that biological plasma effects are mainly mediated by reactive oxygen and nitrogen species, and describes the dose-dependent effects of cold plasma.

  5. Plasma Medicine: Applications of Cold Atmospheric Pressure Plasma in Dermatology

    Bernhardt T, et al. · Oxidative Medicine and Cellular Longevity 2019:3873928 · 2019

    Review of cold atmospheric plasma in dermatology: antimicrobial, anti-inflammatory and tissue-stimulating effects, and the plasma sources in use.

  6. Plasma medicine: possible applications in dermatology

    Heinlin J, et al. · JDDG – Journal der Deutschen Dermatologischen Gesellschaft 8(12):968–976 · 2010

    Overview of possible dermatological uses of plasma, including tissue regeneration and skin infections.

  7. Plasma medicine: an introductory review

    Kong MG, Kroesen G, Morfill G, et al. · New Journal of Physics 11:115012 · 2009

    Introductory review of the field: how room-temperature, atmospheric-pressure plasmas work and where they can be used in health care and hygiene.

Clinical studies

  1. A Prospective, Randomised, Controlled, Split-Face Clinical Trial to Assess the Safety and the Efficacy of Cold Atmospheric Plasma in the Treatment of Acne Vulgaris

    Karrer S, et al. · Applied Sciences 11(23):11181 · 2021

    Split-face trial (34 patients): cold helium plasma was safe and well tolerated, with a moderate reduction in acne lesions and better patient ratings of appearance on the treated side.

  2. Successful and safe use of 2 min cold atmospheric argon plasma in chronic wounds: results of a randomized controlled trial

    Isbary G, et al. · British Journal of Dermatology 167(2):404–410 · 2012

    Randomized controlled study (24 patients): 2-minute cold argon plasma treatments reduced bacterial load without side effects.

  3. A first prospective randomized controlled trial to decrease bacterial load using cold atmospheric argon plasma on chronic wounds in patients

    Isbary G, et al. · British Journal of Dermatology 163(1):78–82 · 2010

    Randomized controlled phase II study (38 wounds, 36 patients): daily cold argon plasma reduced bacterial load in treated wounds by 34% and was well tolerated.

  4. Evaluation of plasma skin regeneration technology in low-energy full-facial rejuvenation

    Bogle MA, Arndt KA, Dover JS · Archives of Dermatology 143(2):168–174 · 2007

    Small study (8 volunteers) of thermal nitrogen-plasma skin regeneration: three low-energy full-face treatments improved facial wrinkles and appearance with short recovery.

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Knowledge leads to better outcomes.

Understanding the science behind Fusion Plasma helps you choose the right protocols, set accurate patient expectations, and deliver consistent clinical results.

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